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Thalidomide, the prototype of the immunomodulatory drugs, yields main erythroid responses in some sufferers with early MDS, but doselimiting neurologic toxicities restrict its potential medical benefit. Fatal opposed reactions occurred in 6 sufferers (1.5%) receiving REVLIMID + rituximab throughout both trials.
They famous that it is licensed for first-line therapy but is not used in this method, that it is available through the Most cancers Medicine Fund for relapsed multiple myeloma the place other therapies aren't applicable, and that it's used in medical follow as fourth- and fifth-line treatment.
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